Novel protein glycan side-chain biomarker and risk of incident type 2 diabetes mellitus.

ABSTRACT:

Objectives

Enzymatically glycosylated proteins partake in multiple biological processes, including glucose transport and inflammation. We hypothesized that a novel biomarker (GlycA) of N-acetyl methyl groups originating mainly from N-acetylglucosamine moieties of acute-phase glycoproteins is related to incident type 2 diabetes mellitus and compared it with high-sensitivity C-reactive protein.

Approach and results

In 26,508 initially healthy women free of diabetes mellitus, baseline GlycA and high-sensitivity C-reactive protein were quantified by nuclear magnetic resonance spectroscopy and immunoturbidimetry, respectively. During median follow-up of 17.2 years, 2087 type 2 diabetes mellitus cases occurred. In Cox models with adjustment for age, race, smoking, alcohol, activit

SUBMITTER: Akinkuolie AO 

PROVIDER: S-EPMC4441588 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature