Forkhead box O-1 modulation improves endothelial insulin resistance in human obesity.

ABSTRACT:

Objective

Increased visceral adiposity has been closely linked to insulin resistance, endothelial dysfunction, and cardiometabolic disease in obesity, but pathophysiological mechanisms are poorly understood. We sought to investigate mechanisms of vascular insulin resistance by characterizing depot-specific insulin responses and gain evidence that altered functionality of transcription factor forkhead box O-1 (FOXO-1) may play an important role in obesity-related endothelial dysfunction.

Approach and results

We intraoperatively collected paired subcutaneous and visceral adipose tissue samples from 56 severely obese (body mass index, 43 ± 7 kg/m(2)) and 14 nonobese subjects during planned surgical operations, and characterized depot-specific insulin-mediated responses using We

SUBMITTER: Karki S 

PROVIDER: S-EPMC4441602 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature