Genetic markers of Restless Legs Syndrome in Parkinson disease.

ABSTRACT:

Introduction

Several studies proposed that Restless Legs Syndrome (RLS) and Parkinson disease (PD) may be clinically and/or etiologically related. To examine this hypothesis, we aimed to determine whether the known RLS genetic markers may be associated with PD risk, as well as with PD subtype.

Methods

Two case-control cohorts from Tel-Aviv and New-York, including 1133 PD patients and 867 controls were genotyped for four RLS-related SNPs in the genes MEIS1, BTBD9, PTPRD and MAP2K5/SKOR1. The association between genotype, PD risk and phenotype was tested using multivariate regression models.

Results

None of the tested SNPs was significantly associated with PD risk, neither in any individual cohort nor in the combined analysis after correction for multiple comparisons. T

SUBMITTER: Gan-Or Z 

PROVIDER: S-EPMC4441838 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature