Perivascular adipose adiponectin correlates with symptom status of patients undergoing carotid endarterectomy.

ABSTRACT:

Background and purpose

Recent symptoms stand as a major determinant of stroke risk in patients with carotid stenosis, likely reflective of atherosclerotic plaque destabilization. In view of emerging links between vascular and adipose biology, we hypothesized that human perivascular adipose characteristics associate with carotid disease symptom status.

Methods

Clinical history, carotid plaques, blood, and subcutaneous and perivascular adipose tissues were prospectively collected from patients undergoing carotid endarterectomy. Nine adipose-associated biological mediators were assayed and compared in patients with symptomatic (n=15) versus asymptomatic (n=19) disease. Bonferroni correction was performed for multiple testing (α/9=0.006).

Results

Symptomatic patients had

SUBMITTER: Sharma G 

PROVIDER: S-EPMC4442051 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature