White matter hyperintensities in middle-aged adults with childhood-onset type 1 diabetes.

ABSTRACT:

Objective

Although microvascular complications are common in type 1 diabetes mellitus (T1DM), few studies have quantified the severity, risk factors, and implications of cerebral microvascular damage in these patients. As life expectancy in patients with T1DM increases, patients are exposed to age- and disease-related factors that may contribute to cerebral microvascular disease.

Methods

Severity and volume of white matter hyperintensities (WMH) and infarcts were quantified in 97 middle-aged patients with childhood-onset T1DM (mean age and duration: 50 and 41 years, respectively) and 81 non-T1DM adults (mean age: 48 years), concurrent with cognitive and health-related measures.

Results

Compared with non-T1DM participants, patients had more severe WMH (Fazekas scores 2

SUBMITTER: Nunley KA 

PROVIDER: S-EPMC4442104 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature