Actin cytoskeletal remodeling with protrusion formation is essential for heart regeneration in Hippo-deficient mice.

ABSTRACT: The mammalian heart regenerates poorly, and damage commonly leads to heart failure. Hippo signaling is an evolutionarily conserved kinase cascade that regulates organ size during development and prevents adult mammalian cardiomyocyte regeneration by inhibiting the transcriptional coactivator Yap, which also responds to mechanical signaling in cultured cells to promote cell proliferation. To identify Yap target genes that are activated during cardiomyocyte renewal and regeneration, we performed Yap chromatin immunoprecipitation sequencing (ChIP-Seq) and mRNA expression profiling in Hippo signaling-deficient mouse hearts. We found that Yap directly regulated genes encoding cell cycle progression proteins, as well as genes encoding proteins that promote F-actin polymerization and that link th

SUBMITTER: Morikawa Y 

PROVIDER: S-EPMC4442128 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature