Dynamics of the cytotoxic T cell response to a model of acute viral infection.

ABSTRACT:

Unlabelled

A detailed characterization of the dynamics and breadth of the immune response to an acute viral infection, as well as the determinants of recruitment to immunological memory, can greatly contribute to our basic understanding of the mechanics of the human immune system and can ultimately guide the design of effective vaccines. In addition to neutralizing antibodies, T cells have been shown to be critical for the effective resolution of acute viral infections. We report the first in-depth analysis of the dynamics of the CD8(+) T cell repertoire at the level of individual T cell clonal lineages upon vaccination of human volunteers with a single dose of YF-17D. This live attenuated yellow fever virus vaccine yields sterile, long-term immunity and has been previously used as

SUBMITTER: DeWitt WS 

PROVIDER: S-EPMC4442358 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature