Receptor usage and cell entry of porcine epidemic diarrhea coronavirus.

ABSTRACT: Porcine epidemic diarrhea coronavirus (PEDV) has significantly damaged America's pork industry. Here we investigate the receptor usage and cell entry of PEDV. PEDV recognizes protein receptor aminopeptidase N from pig and human and sugar coreceptor N-acetylneuraminic acid. Moreover, PEDV infects cells from pig, human, monkey, and bat. These results support the idea of bats as an evolutionary origin for PEDV, implicate PEDV as a potential threat to other species, and suggest antiviral strategies to control its spread.

SUBMITTER: Liu C 

PROVIDER: S-EPMC4442452 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature