A Systematic Meta-analysis of Immune Signatures in Patients With Acute Chikungunya Virus Infection.

ABSTRACT:

Background

Individuals infected with chikungunya virus (CHIKV) normally exhibit a variety of clinical manifestations during the acute phase of infection. However, studies in different patient cohorts have revealed that disease manifestations vary in frequency.

Methods

Disease profiles between patients with acute CHIKV-infection and febrile patients without CHIKV were compared and examined to determine whether any clinical presentations were associated with the clinical outcome of CHIKV infection. Circulatory immune mediators profiles were then characterized and compared with data from 14 independent patient cohort studies. The particular immune mediator signature that defines acute CHIKV infection was determined.

Results

Our findings revealed a specific pattern of cli

SUBMITTER: Teng TS 

PROVIDER: S-EPMC4442625 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature