Hyperpolarization of "Neat" Liquids by NMR Signal Amplification by Reversible Exchange.

ABSTRACT: We report NMR Signal Amplification by Reversible Exchange (SABRE) hyperpolarization of the rare isotopes in "neat" liquids, each composed only of an otherwise pure target compound with isotopic natural abundance (n.a.) and millimolar concentrations of dissolved catalyst. Pyridine (Py) or Py derivatives are studied at 0.4% isotopic natural abundance ¹⁵N, deuterated, ¹⁵N enriched, and in various combinations using the SABRE-SHEATH variant (microTesla magnetic fields to permit direct ¹⁵N polarization from parahydrogen via reversible binding and exchange with an Ir catalyst). We find that the dilute n.a. ¹⁵N spin bath in Py still channels spin order from parahydrogen to dilute ¹⁵N spins, without polarization losses due to the presence of ¹⁴N or ²H. We demonstrate P(15N) ≈ 1% (a gain of 2900 fo

SUBMITTER: Shchepin RV 

PROVIDER: S-EPMC4442667 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature