Genomewide linkage analysis in Costa Rican families implicates chromosome 15q14 as a candidate region for OCD.

ABSTRACT: Obsessive compulsive disorder (OCD) has a complex etiology that encompasses both genetic and environmental factors. However, to date, despite the identification of several promising candidate genes and linkage regions, the genetic causes of OCD are largely unknown. The objective of this study was to conduct linkage studies of childhood-onset OCD, which is thought to have the strongest genetic etiology, in several OCD-affected families from the genetically isolated population of the Central Valley of Costa Rica (CVCR). The authors used parametric and non-parametric approaches to conduct genome-wide linkage analyses using 5,786 single nucleotide repeat polymorphisms (SNPs) in three CVCR families with multiple childhood-onset OCD-affected individuals. We identified areas of suggestive linkage

SUBMITTER: Ross J 

PROVIDER: S-EPMC4442699 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature