Effects of xanthine oxidase inhibitors on cardiovascular disease in patients with gout: a cohort study.

ABSTRACT:

Background

Hyperuricemia and gout are associated with an increased risk of cardiovascular disease (CVD). It is unknown whether treating hyperuricemia with xanthine oxidase inhibitors (XOIs), including allopurinol and febuxostat, modifies cardiovascular risks.

Methods

We used US insurance claims data to conduct a cohort study among gout patients, comparing XOI initiators with non-users with hyperuricemia defined as serum uric acid level ≥6.8 mg/dL. We calculated incidence rates of a composite nonfatal cardiovascular outcome that included myocardial infarction, coronary revascularization, stroke, and heart failure. Propensity score (PS)-matched Cox proportional hazards regression compared the risk of composite cardiovascular endpoint in XOI initiators vs those with untreated h

SUBMITTER: Kim SC 

PROVIDER: S-EPMC4442710 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature