Absence of cytochrome P450 2A5 enhances alcohol-induced liver injury in mice.

ABSTRACT:

Background

Ethanol can induce cytochrome P450 2E1, an active generator of reactive oxygen species, and this cytochrome is considered a risk factor for oxidative liver injury. Recently, we found that in addition to P450 2E1 also cytochrome P450 2A5, another isoform of cytochrome P450, can be induced by ethanol, and that ethanol induction of cytochrome P450 2A5 is P450 2E1-dependent.

Aims

To investigate the role of cytochrome P450 2A5 in alcohol-induced liver injury.

Methods

Cytochrome P450 2A5-knockout mice and wild type mice were fed the Lieber-Decarli ethanol liquid diet to induce liver injury. Controls were fed the Lieber-Decarli control diet.

Results

After 4 weeks of feeding with Lieber-Decarli diet, ethanol-induced liver injury was enhanced in the knockout

SUBMITTER: Hong F 

PROVIDER: S-EPMC4442740 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature