Ryanodine receptor gating controls generation of diastolic calcium waves in cardiac myocytes.

ABSTRACT: The role of cardiac ryanodine receptor (RyR) gating in the initiation and propagation of calcium waves was investigated using a mathematical model comprising a stochastic description of RyR gating and a deterministic description of calcium diffusion and sequestration. We used a one-dimensional array of equidistantly spaced RyR clusters, representing the confocal scanning line, to simulate the formation of calcium sparks. Our model provided an excellent description of the calcium dependence of the frequency of diastolic calcium sparks and of the increased tendency for the production of calcium waves after a decrease in cytosolic calcium buffering. We developed a hypothesis relating changes in the propensity to form calcium waves to changes of RyR gating and tested it by simulation. With a r

SUBMITTER: Petrovic P 

PROVIDER: S-EPMC4442793 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature