MTHFR gene C677T polymorphism and type 2 diabetic nephropathy in Asian populations: a meta-analysis.

ABSTRACT:

Background

Many studies have suggested a correlation between the C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene and diabetic nephropathy (DN), but their results are inconclusive.

Methods

To confirm this correlation, we performed a meta-analysis of 15 studies. The dichotomous data are presented as odds ratios (OR) with 95% confidence intervals (CI).

Results

The results of this study suggested that the MTHFR 677 T allele was more likely to increase the risk of DN in Asian (OR = 1.466, 95% CI = 1.143-1.880, P = 0.003), West Asian (OR = 1.750, 95% CI = 1.150-2.664, P = 0.009), and Chinese populations (OR = 2.162, 95% CI = 1.719-2.719, P = 0.001), but not in East Asian or Japanese populations. The carriers of the MTHFR 677 T allele were associated w

SUBMITTER: Chen H 

PROVIDER: S-EPMC4443095 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature