Carriage of NBN polymorphisms and acute leukemia risk.

ABSTRACT:

Background

Recent reports revealed a significant association of NBN polymorphisms with risk of acute leukemia among Chinese, but not among Europeans. The objective of this study was to obtain a more precise measure of acute leukemia risk associated with NBN rs1805794, rs2735383, rs709816 polymorphisms.

Methods

Using PubMed, Embase, ISI Web of Science, and the Cochrane Library databases, we undertook a systematic literature search up to September 1, 2014. Eligible studies were singled out from 31 possibly related publications by two investigators. Based on the extracted NBN genotypes, we calculated pooled odds ratios (ORs) and 95% confidence intervals (95% CI) by use of the random effects model proposed by DerSimonian and Laird.

Results

We finally derived 3,065 subject

SUBMITTER: Wang Y 

PROVIDER: S-EPMC4443107 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature