Differential effects of fructose versus glucose on brain and appetitive responses to food cues and decisions for food rewards.

ABSTRACT: Prior studies suggest that fructose compared with glucose may be a weaker suppressor of appetite, and neuroimaging research shows that food cues trigger greater brain reward responses in a fasted relative to a fed state. We sought to determine the effects of ingesting fructose versus glucose on brain, hormone, and appetitive responses to food cues and food-approach behavior. Twenty-four healthy volunteers underwent two functional magnetic resonance imaging (fMRI) sessions with ingestion of either fructose or glucose in a double-blinded, random-order cross-over design. fMRI was performed while participants viewed images of high-calorie foods and nonfood items using a block design. After each block, participants rated hunger and desire for food. Participants also performed a decision task in

SUBMITTER: Luo S 

PROVIDER: S-EPMC4443321 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature