Ontology highlight
ABSTRACT:
SUBMITTER: Bardy C
PROVIDER: S-EPMC4443325 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20150413 20
Human cell reprogramming technologies offer access to live human neurons from patients and provide a new alternative for modeling neurological disorders in vitro. Neural electrical activity is the essence of nervous system function in vivo. Therefore, we examined neuronal activity in media widely used to culture neurons. We found that classic basal media, as well as serum, impair action potential generation and synaptic communication. To overcome this problem, we designed a new neuronal medium ( ...[more]