Association between interleukin-18 gene promoter (- 607C/A and - 137G/C) polymorphisms and chronic hepatitis C virus infections: A meta-analysis.

ABSTRACT:

Objective

HCV infection has a chronicity rate of about 70%, several studies have shown that interleukin-18 (IL-18) was associated with etiology and progression of hepatitis C virus (HCV) infections. However, the association between single-nucleotide polymorphisms - 607C/A (rs1946518) and - 137G/C (rs187238) located in the IL-18 gene promoter and chronic hepatitis C virus infections was still controversial and ambiguous. To derive a more precise effect on the association between these polymorphisms and chronic hepatitis C virus infections, we performed this first meta-analysis based on the currently available evidence of the literature.

Methods

A total of 4 studies with 1222 cases and 1115 controls for - 607C/A polymorphism and 3 studies with 959 cases and 987 controls for - 

SUBMITTER: Yang Y 

PROVIDER: S-EPMC4443429 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature