Very low levels of atherogenic lipoproteins and the risk for cardiovascular events: a meta-analysis of statin trials.

ABSTRACT:

Background

Levels of atherogenic lipoproteins achieved with statin therapy are highly variable, but the consequence of this variability for cardiovascular disease risk is not well-documented.

Objectives

The aim of this meta-analysis was to evaluate: 1) the interindividual variability of reductions in low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), or apolipoprotein B (apoB) levels achieved with statin therapy; 2) the proportion of patients not reaching guideline-recommended lipid levels on high-dose statin therapy; and 3) the association between very low levels of atherogenic lipoproteins achieved with statin therapy and cardiovascular disease risk.

Methods

This meta-analysis used individual patient data from 8 random

SUBMITTER: Boekholdt SM 

PROVIDER: S-EPMC4443441 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature