Domain similarity based orthology detection.

ABSTRACT:

Background

Orthologous protein detection software mostly uses pairwise comparisons of amino-acid sequences to assert whether two proteins are orthologous or not. Accordingly, when the number of sequences for comparison increases, the number of comparisons to compute grows in a quadratic order. A current challenge of bioinformatic research, especially when taking into account the increasing number of sequenced organisms available, is to make this ever-growing number of comparisons computationally feasible in a reasonable amount of time. We propose to speed up the detection of orthologous proteins by using strings of domains to characterize the proteins.

Results

We present two new protein similarity measures, a cosine and a maximal weight matching score based on domain content

SUBMITTER: Bitard-Feildel T 

PROVIDER: S-EPMC4443542 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature