Electrophysiological biomarkers of neuromodulatory strategies to recover motor function after spinal cord injury.

ABSTRACT: The spinal cord contains the circuitry to control posture and locomotion after complete paralysis, and this circuitry can be enabled with epidural stimulation [electrical enabling motor control (eEmc)] and/or administration of pharmacological agents [pharmacological enabling motor control (fEmc)] when combined with motor training. We hypothesized that the characteristics of the spinally evoked potentials after chronic administration of both strychnine and quipazine under the influence of eEmc during standing and stepping can be used as biomarkers to predict successful motor performance. To test this hypothesis we trained rats to step bipedally for 7 wk after paralysis and characterized the motor potentials evoked in the soleus and tibialis anterior (TA) muscles with the rats in a non-weigh

SUBMITTER: Gad P 

PROVIDER: S-EPMC4443610 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature