Epigenetic mechanisms of endothelial dysfunction in type 2 diabetes.

ABSTRACT: The development of type-2 diabetes mellitus (T2DM) and its complications is largely due to the complex interaction between genetic factors and environmental influences, mainly dietary habits and lifestyle, which can either accelerate or slow down disease progression. Recent findings suggest the potential involvement of epigenetic mechanisms as a crucial interface between the effects of genetic predisposition and environmental factors. The common denominator of environmental factors promoting T2DM development and progression is that they trigger an inflammatory response, promoting inflammation-mediated insulin resistance and endothelial dysfunction. Proinflammatory stimuli, including hyperglycemia, oxidative stress, and other inflammatory mediators, can affect epigenetic mechanisms, alterin

SUBMITTER: Prattichizzo F 

PROVIDER: S-EPMC4443613 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature