Integrative modeling reveals the principles of multi-scale chromatin boundary formation in human nuclear organization.

ABSTRACT:

Background

Interphase chromosomes adopt a hierarchical structure, and recent data have characterized their chromatin organization at very different scales, from sub-genic regions associated with DNA-binding proteins at the order of tens or hundreds of bases, through larger regions with active or repressed chromatin states, up to multi-megabase-scale domains associated with nuclear positioning, replication timing and other qualities. However, we have lacked detailed, quantitative models to understand the interactions between these different strata.

Results

Here we collate large collections of matched locus-level chromatin features and Hi-C interaction data, representing higher-order organization, across three human cell types. We use quantitative modeling approaches to assess

SUBMITTER: Moore BL 

PROVIDER: S-EPMC4443654 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature