GenoExp: a web tool for predicting gene expression levels from single nucleotide polymorphisms.

ABSTRACT:

Unlabelled

Understanding the effect of single nucleotide polymorphisms (SNPs) on the expression level of genes is an important goal. We recently published a study in which we devised a multi-SNP predictive model for gene expression in Lymphoblastoid cell lines (LCL), and showed that it can robustly predict the expression of a small number of genes in test individuals. Here, we validate the generality of our models by predicting expression profiles for genes in LCL in an independent study, and extend the pool of predictable genes for which we are able to explain more than 25% of their expression variability to 232 genes across 14 different cell types. As the number of people who obtained their SNP profiles through companies such as 23andMe is rising rapidly, we developed GenoExp, a

SUBMITTER: Manor O 

PROVIDER: S-EPMC4443679 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature