Polymorphisms of the vincristine pathway and response to treatment in children with childhood acute lymphoblastic leukemia.

ABSTRACT:

Background

Vincristine (VCR) is a standard component in the treatment of childhood acute lymphoblastic leukemia (ALL). VCR cytotoxicity is primarily due to its ability to disrupt the formation of microtubules of the mitotic spindle.

Patients & methods

Seventeen polymorphisms in regulatory and coding regions of genes controlling VCR targets (TUBB1, MAP4, ACTG1 and CAPG) or potentially influencing VCR levels (ABCB1 and CYP3A5) were investigated for an association with peripheral neuropathy and outcome in childhood ALL patients.

Results

High-grade neurotoxicity was more frequent in carriers of the A allele of synonymous (Ala310) G to A (rs1135989) variation in the ACTG1 gene. Substitution (rs4728709) in the promoter of the ABCB1 gene had a protective effect against lower

SUBMITTER: Ceppi F 

PROVIDER: S-EPMC4443746 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature