Ontology highlight
ABSTRACT:
SUBMITTER: Rook JM
PROVIDER: S-EPMC4443790 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Rook Jerri M JM Xiang Zixiu Z Lv Xiaohui X Ghoshal Ayan A Dickerson Jonathan W JW Bridges Thomas M TM Johnson Kari A KA Foster Daniel J DJ Gregory Karen J KJ Vinson Paige N PN Thompson Analisa D AD Byun Nellie N Collier Rebekah L RL Bubser Michael M Nedelcovych Michael T MT Gould Robert W RW Stauffer Shaun R SR Daniels J Scott JS Niswender Colleen M CM Lavreysen Hilde H Mackie Claire C Conde-Ceide Susana S Alcazar Jesus J Bartolomé-Nebreda José M JM Macdonald Gregor J GJ Talpos John C JC Steckler Thomas T Jones Carrie K CK Lindsley Craig W CW Conn P Jeffrey PJ
Neuron 20150430 4
Schizophrenia is associated with disruptions in N-methyl-D-aspartate glutamate receptor subtype (NMDAR)-mediated excitatory synaptic signaling. The metabotropic glutamate receptor subtype 5 (mGlu5) is a closely associated signaling partner with NMDARs and regulates NMDAR function in forebrain regions implicated in the pathology of schizophrenia. Efficacy of mGlu5 positive allosteric modulators (PAMs) in animal models of psychosis and cognition was previously attributed to potentiation of NMDAR f ...[more]