Systems reconsolidation reveals a selective role for the anterior cingulate cortex in generalized contextual fear memory expression.

ABSTRACT: After acquisition, hippocampus-dependent memories undergo a systems consolidation process, during which they become independent of the hippocampus and dependent on the anterior cingulate cortex (ACC) for memory expression. However, consolidated remote memories can become transiently hippocampus-dependent again following memory reactivation. How this systems reconsolidation affects the role of the ACC in remote memory expression is not known. Using contextual fear conditioning, we show that the expression of 30-day-old remote memory can transiently be supported by either the ACC or the dorsal hippocampus following memory reactivation, and that the ACC specifically mediates expression of remote generalized contextual fear memory. We found that suppression of neural activity in the ACC with t

SUBMITTER: Einarsson EO 

PROVIDER: S-EPMC4443963 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature