Effects of centrally administered etanercept on behavior, microglia, and astrocytes in mice following a peripheral immune challenge.

ABSTRACT: Peripheral cytokines affect central nervous system (CNS) function, manifesting in symptoms of anxiety and cognitive decline. Although the peripheral blockage of tumor necrosis factor (TNF)-α has been effective in alleviating depression and rheumatoid arthritis, it is yet unknown whether central blockade of TNF-α is beneficial for immune-challenged CNS function. This study investigated the effects of central etanercept administration following a peripheral immune challenge on anxiety-like and cognition-like behaviors and microglia and astrocyte numbers. Twelve-week-old C57BL/6 mice (n=40) were treated with either LPS or saline administered peripherally 24 h before being treated with either etanercept or artificial CSF (aCSF) by intracerebroventricular injection. Mice underwent behavioral an

SUBMITTER: Camara ML 

PROVIDER: S-EPMC4443965 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature