Repeated social stress increases reward salience and impairs encoding of prediction by rat locus coeruleus neurons.

ABSTRACT: Stress is implicated in psychopathology characterized by cognitive dysfunction. Cognitive responses to stress are regulated by the locus coeruleus-norepinephrine (LC-NE) system. As social stress is a prevalent human stressor, this study determined the impact of repeated social stress on the relationship between LC neuronal activity and behavior during the performance of cognitive tasks. Social stress-exposed rats performed better at intradimensional set shifting (IDS) and made fewer perseverative errors during reversal learning (REV). LC neurons of control rats were task responsive, being activated after the choice and before reward. Social stress shifted LC neuronal activity from being task responsive to being reward responsive during IDS and REV. LC neurons of stressed rats were activate

SUBMITTER: Chaijale NN 

PROVIDER: S-EPMC4443966 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature