AMP-Activated Protein Kinase Regulates the Cell Surface Proteome and Integrin Membrane Traffic.

ABSTRACT: The cell surface proteome controls numerous cellular functions including cell migration and adhesion, intercellular communication and nutrient uptake. Cell surface proteins are controlled by acute changes in protein abundance at the plasma membrane through regulation of endocytosis and recycling (endomembrane traffic). Many cellular signals regulate endomembrane traffic, including metabolic signaling; however, the extent to which the cell surface proteome is controlled by acute regulation of endomembrane traffic under various conditions remains incompletely understood. AMP-activated protein kinase (AMPK) is a key metabolic sensor that is activated upon reduced cellular energy availability. AMPK activation alters the endomembrane traffic of a few specific proteins, as part of an adaptive re

SUBMITTER: Ross E 

PROVIDER: S-EPMC4444004 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature