Parathyroid hormone, cognitive function and dementia: a systematic review.

ABSTRACT:

Background

Metabolic factors are increasingly recognized to play an important role in the pathogenesis of Alzheimer's disease and dementia. Abnormal parathyroid hormone (PTH) levels play a role in neuronal calcium dysregulation, hypoperfusion and disrupted neuronal signaling. Some studies support a significant link between PTH levels and dementia whereas others do not.

Methods

We conducted a systematic review through January 2014 to evaluate the association between PTH and parathyroid conditions, cognitive function and dementia. Eleven electronic databases and citation indexes were searched including Medline, Embase and the Cochrane Library. Hand searches of selected journals, reference lists of primary studies and reviews were also conducted along with websites of key organ

SUBMITTER: Lourida I 

PROVIDER: S-EPMC4444118 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature