Telomere length attrition and chronic periodontitis: an ARIC Study nested case-control study.

ABSTRACT:

Aim

This nested case-control study sought to determine whether an accelerated rate of leukocyte telomere length (LTL) shortening over 6 years was associated with chronic periodontitis.

Materials and methods

We sampled cases (n = 178) with severe chronic periodontitis and controls (n = 178) with no/mild chronic periodontitis from the Atherosclerosis Risk in Communities study. Controls were frequency-matched to cases by study site, age, sex and race. Age ranged from 53 to 73 years. Severe chronic periodontitis was defined using the CDC-AAP case classification. LTL was measured from DNA collected at two time points, 6 years apart, with quantitative polymerase chain reaction relative to a single-copy control gene. Multiple linear regression evaluated associations between LTL mea

SUBMITTER: Sanders AE 

PROVIDER: S-EPMC4444215 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature