A detailed family history of myocardial infarction and risk of myocardial infarction--a nationwide cohort study.

ABSTRACT:

Background

Family history of myocardial infarction (MI) is an independent risk factor for MI. Several genetic variants are associated with increased risk of MI and family history of MI in a first-degree relative doubles MI risk. However, although family history of MI is not a simple dichotomous risk factor, the impact of specific, detailed family histories has not received much attention, despite its high clinical relevance. We examined risk of MI by MIs in first- and second-degree relatives and by number and age of affected relatives.

Methods and findings

Using Danish national registers, we established a nationwide cohort of persons born between 1930 and 1992 with identifiable first- or second-degree relatives. Incident MIs in both cohort members and relatives aged ≥20 year

SUBMITTER: Ranthe MF 

PROVIDER: S-EPMC4444238 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature