A First Generation Comparative Chromosome Map between Guinea Pig (Cavia porcellus) and Humans.

ABSTRACT: The domesticated guinea pig, Cavia porcellus (Hystricomorpha, Rodentia), is an important laboratory species and a model for a number of human diseases. Nevertheless, genomic tools for this species are lacking; even its karyotype is poorly characterized. The guinea pig belongs to Hystricomorpha, a widespread and important group of rodents; so far the chromosomes of guinea pigs have not been compared with that of other hystricomorph species or with any other mammals. We generated full sets of chromosome-specific painting probes for the guinea pig by flow sorting and microdissection, and for the first time, mapped the chromosomal homologies between guinea pig and human by reciprocal chromosome painting. Our data demonstrate that the guinea pig karyotype has undergone extensive rearrangements:

SUBMITTER: Romanenko SA 

PROVIDER: S-EPMC4444286 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature