Reducing In-Stent Restenosis: Therapeutic Manipulation of miRNA in Vascular Remodeling and Inflammation.

ABSTRACT:

Background

Drug-eluting stents reduce the incidence of in-stent restenosis, but they result in delayed arterial healing and are associated with a chronic inflammatory response and hypersensitivity reactions. Identifying novel interventions to enhance wound healing and reduce the inflammatory response may improve long-term clinical outcomes. Micro-ribonucleic acids (miRNAs) are noncoding small ribonucleic acids that play a prominent role in the initiation and resolution of inflammation after vascular injury.

Objectives

This study sought to identify miRNA regulation and function after implantation of bare-metal and drug-eluting stents.

Methods

Pig, mouse, and in vitro models were used to investigate the role of miRNA in in-stent restenosis.

Results

We documented

SUBMITTER: McDonald RA 

PROVIDER: S-EPMC4444526 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature