Exclusion of integrins from CNS axons is regulated by Arf6 activation and the AIS.

ABSTRACT: Integrins are adhesion and survival molecules involved in axon growth during CNS development, as well as axon regeneration after injury in the peripheral nervous system (PNS). Adult CNS axons do not regenerate after injury, partly due to a low intrinsic growth capacity. We have previously studied the role of integrins in axon growth in PNS axons; in the present study, we investigate whether integrin mechanisms involved in PNS regeneration may be altered or lacking from mature CNS axons by studying maturing CNS neurons in vitro. In rat cortical neurons, we find that integrins are present in axons during initial growth but later become restricted to the somato-dendritic domain. We investigated how this occurs and whether it can be altered to enhance axonal growth potential. We find a develop

SUBMITTER: Franssen EH 

PROVIDER: S-EPMC4444552 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature