Sdf-1 (CXCL12) induces CD9 expression in stem cells engaged in muscle regeneration.

ABSTRACT:

Introduction

Understanding the mechanism of stem cell mobilization into injured skeletal muscles is a prerequisite step for the development of muscle disease therapies. Many of the currently studied stem cell types present myogenic potential; however, when introduced either into the blood stream or directly into the tissue, they are not able to efficiently engraft injured muscle. For this reason their use in therapy is still limited. Previously, we have shown that stromal-derived factor-1 (Sdf-1) caused the mobilization of endogenous (not transplanted) stem cells into injured skeletal muscle improving regeneration. Here, we demonstrate that the beneficial effect of Sdf-1 relies on the upregulation of the tetraspanin CD9 expression in stem cells.

Methods

The expression patter

SUBMITTER: Brzoska E 

PROVIDER: S-EPMC4445299 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature