Genetics of juvenile idiopathic arthritis: new tools bring new approaches.

ABSTRACT:

Purpose of review

In juvenile idiopathic arthritis (JIA), there are now more than 25 regions represented by single nucleotide polymorphisms that show strong genetic associations. The causal variants and corresponding functions have not yet been defined for the majority of these regions. Here, we review current JIA association findings and the recent progress in the annotation of noncoding portion of the human genome as well as the new technologies necessary to apply this knowledge to JIA association findings.

Recent findings

An international collaboration was able to amass sufficient numbers of JIA and control samples to identify significantly robust genetic associations for JIA. The Encyclopedia of DNA Elements project and the National Institutes of Health (NIH) Roadmap Epi

SUBMITTER: Moncrieffe H 

PROVIDER: S-EPMC4445412 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature