Comprehensive survey of condition-specific reproductive isolation reveals genetic incompatibility in yeast.

ABSTRACT: Genetic variation within a species could cause negative epistasis leading to reduced hybrid fitness and post-zygotic reproductive isolation. Recent studies in yeasts revealed chromosomal rearrangements as a major mechanism dampening intraspecific hybrid fertility on rich media. Here, by analysing a large number of Saccharomyces cerevisiae crosses on different culture conditions, we show environment-specific genetic incompatibility segregates readily within yeast and contributes to reproductive isolation. Over 24% (117 out of 481) of cases tested show potential epistasis, among which 6.7% (32 out of 481) are severe, with at least 20% of progeny loss on tested conditions. Based on the segregation patterns, we further characterize a two-locus Dobzhansky-Müller incompatibility case leading to

SUBMITTER: Hou J 

PROVIDER: S-EPMC4445460 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature