Soft tissue sarcoma, non-Hodgkin's lymphoma and chronic lymphocytic leukaemia in workers exposed to phenoxy herbicides: extended follow-up of a UK cohort.

ABSTRACT:

Objectives

To provide further information on the possible carcinogenicity of phenoxy herbicides, and in particular their relationship to soft tissue sarcoma (STS), non-Hodgkin's lymphoma (NHL) and chronic lymphocytic leukaemia (CLL).

Methods

We extended follow-up to December 2012 for 8036 men employed at five factories in the UK which had manufactured phenoxy herbicides, or in a contract spraying business. Mortality was compared with that for England and Wales by the person-years method. Nested case-control analyses compared men with incident or fatal STS (n=15) or NHL/CLL (n=74) and matched controls (up to 10 per case).

Results

4093 men had died, including 2303 since the last follow-up. Mortality from all causes and all cancers was close to expectation, but an excess

SUBMITTER: Coggon D 

PROVIDER: S-EPMC4445603 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature