Case-control estimation of the impact of oncolytic adenovirus on the survival of patients with refractory solid tumors.

ABSTRACT: Oncolytic immunotherapy with cytokine armed replication competent viruses is an emerging approach in cancer treatment. In a recent randomized trial, an increase in response rate was seen but the effect on overall survival is not known with any virus. To facilitate randomized trials, we performed a case-control study assessing the survival of 270 patients treated in an Advanced Therapy Access Program (ATAP), in comparison to matched concurrent controls from the same hospital. The overall survival of all virus treated patients was not increased over controls. However, when analysis was restricted to GMCSF-sensitive tumor types treated with GMSCF-coding viruses, a significant improvement in median survival was present (from 170 to 208 days, P = 0.0012, N = 148). An even larger difference was

SUBMITTER: Kanerva A 

PROVIDER: S-EPMC4445619 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature