Atlas of tissue renin-angiotensin-aldosterone system in human: A transcriptomic meta-analysis.

ABSTRACT: Tissue renin-angiotensin-aldosterone system (RAAS) has attracted much attention because of its physiological and pharmacological implications; however, a clear definition of tissue RAAS is still missing. We aimed to establish a preliminary atlas for the organization of RAAS across 23 different normal human tissues. A set of 37 genes encoding classical and novel RAAS participants including gluco- and mineralo-corticoids were defined as extended RAAS (extRAAS) system. Microarray data sets containing more than 10 normal tissues were downloaded from the GEO database. R software was used to extract expression levels and construct dendrograms of extRAAS genes within each data set. Tissue co-expression modules were then extracted from reproducible gene clusters across data sets. An atlas of the m

SUBMITTER: Nehme A 

PROVIDER: S-EPMC4445654 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature