Functional and histological improvement after everolimus rescue of chronic allograft dysfunction in renal transplant recipients.

ABSTRACT:

Background

We tested the strategy of mTOR inhibitors with calcineurin inhibitor minimization in renal transplant recipients with known chronic allograft dysfunction.

Methods

In this open-label, single-arm study, renal transplant patients were recruited after biopsy-confirmed chronic allograft dysfunction in the absence of acute rejection episode within 2 months, with proteinuria <0.8 g/day, and serum creatinine <220 μmol/L or estimated glomerular filtration rate >40 mL/min/1.73 m(2). They were converted to everolimus (aiming for trough everolimus level 3-8 ng/mL) with cyclosporine minimization, to assess the effect on renal function, rate of glomerular filtration rate decline, and longitudinal transplant biopsy at 12 months.

Results

Seventeen Chinese patients (median

SUBMITTER: Chow KM 

PROVIDER: S-EPMC4445695 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature