Alkyne hydroacylation: switching regioselectivity by tandem ruthenium catalysis.

ABSTRACT: By using tandem Ru-catalysis, internal alkynes can be coupled with aldehydes for the synthesis of β,γ-unsaturated ketones. The catalyst promotes alkyne transformations with high regioselectivity, with examples that include the differentiation of a methyl vs ethyl substituent on the alkyne. Mechanistic studies suggest that the regioselectivity results from a selective allene formation that is governed by allylic strain.

SUBMITTER: Chen QA 

PROVIDER: S-EPMC4445957 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature