T-cell profile in adipose tissue is associated with insulin resistance and systemic inflammation in humans.

ABSTRACT:

Objective

The biological mechanisms linking obesity to insulin resistance have not been fully elucidated. We have shown that insulin resistance or glucose intolerance in diet-induced obese mice is related to a shift in the ratio of pro- and anti-inflammatory T cells in adipose tissue. We sought to test the hypothesis that the balance of T-cell phenotypes would be similarly related to insulin resistance in human obesity.

Approach and results

Healthy overweight or obese human subjects underwent adipose-tissue biopsies and quantification of insulin-mediated glucose disposal by the modified insulin suppression test. T-cell subsets were quantified by flow cytometry in visceral (VAT) and subcutaneous adipose tissue (SAT). Results showed that CD4 and CD8 T cells infiltrate both dep

SUBMITTER: McLaughlin T 

PROVIDER: S-EPMC4445971 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature