Differential expression and clinical significance of three inflammation-related microRNAs in gangliogliomas.

ABSTRACT:

Purpose

miR21, miR146, and miR155 represent a trio of microRNAs which has been shown to play a key role in the regulation of immune and inflammatory responses. In the present study, we investigated the differential expression and clinical significance of these three miRNAs in glioneuronal tumors (gangliogliomas, GGs) which are characterized by prominent activation of the innate immune response.

Methods

The expression levels of miR21, miR146, and miR155 were evaluated using Taqman PCR in 34 GGs, including 15 cases with sufficient amount of perilesional cortex. Their expression was correlated with the tumor features and the clinical history of epilepsy. In addition, in situ hybridization was used to evaluate their cellular distribution in both tumor and peritumoral cortex.

SUBMITTER: Prabowo AS 

PROVIDER: S-EPMC4446114 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature