Different distribution of histone modifications in genes with unidirectional and bidirectional transcription and a role of CTCF and cohesin in directing transcription.

ABSTRACT:

Background

Several post-translational histone modifications are mainly found in gene promoters and are associated with the promoter activity. It has been hypothesized that histone modifications regulate the transcription, as opposed to the traditional view with transcription factors as the key regulators. Promoters of most active genes do not only initiate transcription of the coding sequence, but also a substantial amount of transcription of the antisense strand upstream of the transcription start site (TSS). This promoter feature has generally not been considered in previous studies of histone modifications and transcription factor binding.

Results

We annotated protein-coding genes as bi- or unidirectional depending on their mode of transcription and compared histone modif

SUBMITTER: Bornelov S 

PROVIDER: S-EPMC4446127 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature