Relationship of thoracic fat depots with coronary atherosclerosis and circulating inflammatory biomarkers.

ABSTRACT:

Objective

The aim of the study was to determine the relationship of various thoracic fat depots with the presence and extent of coronary artery plaque and circulating biomarkers.

Methods

In 342 patients (52 ± 11 years, 61% male, BMI 29.1 ± 5.9 kg/m(2) ) with coronary computed tomography (CT), angiography, we measured the fat volume in four thoracic depots (pericoronary, epicardial, periaortic, extracardiac), assessed coronary plaque, and determined the circulating levels of C-reactive protein, tumor necrosis factor alpha, plasminogen activator inhibitor-1, monocyte chemoattractant protein-1, and adiponectin. The extent of coronary plaque was classified into three groups: 0, 1-3, and >3 segments.

Results

Patients with plaque (n =169, 49%) had higher volumes of all four

SUBMITTER: Maurovich-Horvat P 

PROVIDER: S-EPMC4446160 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature