Influence of the Vitreomacular Interface on Treatment Outcomes in the Comparison of Age-Related Macular Degeneration Treatments Trials.

ABSTRACT:

Objective

To assess the association of the vitreomacular interface with outcomes of eyes treated with anti-vascular endothelial growth factor drugs for neovascular age-related macular degeneration (AMD).

Design

Prospective cohort study within a multicenter, randomized clinical trial.

Participants

Patients enrolled in the Comparison of AMD Treatments Trials (CATT).

Methods

Treatment was assigned randomly as either ranibizumab or bevacizumab and as 3 different regimens for dosing over a 2-year period. Masked readers at a reading center assessed optical coherence tomography (OCT) scans at baseline and follow-up for vitreomacular traction (VMT) and vitreomacular adhesion (VMA), fluid, and central thickness. Visual acuity (VA) was measured by masked, certified exami

SUBMITTER: Ciulla TA 

PROVIDER: S-EPMC4446183 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature